Adjuvanted influenza vaccine 

Adults aged ≥65 years

ATAGI recommendations for Fluad 

Use of adjuvanted influenza vaccine versus standard dose influenza vaccine in adults aged ≥65 years

Use of high-dose influenza vaccine versus adjuvanted influenza vaccine in adults aged ≥65 years

GRADE assessment for Fluad  

Comparison of MF-59 (Fluad) with standard dose influenza vaccine in adults aged ≥65 years

Comparison of MF-59 (Fluad) with high-dose influenza vaccine for people aged ≥65 years

Adults aged 50–64 years

Coversheet for Fluad

Use of MF59-aIIV (Fluad) in adults aged 50–64 years

GRADE assessment and ATAGI recommendation for Fluad

Comparison of MF59-aIIV (Fluad) with standard inactivated influenza vaccine (IIV) for prevention of influenza in adults aged 50–64 years

 

Cell-based influenza vaccine

Coversheet for Flucelvax 

Use of cell-derived influenza vaccine versus egg-based influenza vaccines 

GRADE assessment and ATAGI recommendation for Flucelvax 

PICO 1: Comparison of cell-based influenza vaccine with standard egg-based influenza vaccine in children aged 6 months–17 years 

PICO 2: Comparison of cell-based influenza vaccine with standard egg-based influenza vaccine in adults aged 18–64 years 

PICO 3: Comparison of cell-based influenza vaccine with adjuvanted egg-based influenza vaccine in adults aged ≥65 years 

PICO 4: Comparison of cell-based influenza vaccine with high-dose egg-based influenza vaccine in adults aged ≥65 years 

 

High-dose influenza vaccine 

ATAGI recommendations for Fluzone High-Dose

Use of high-dose influenza vaccine versus standard dose influenza vaccine in adults aged ≥65 years

GRADE assessment for Fluzone High-Dose

Comparison of high-dose influenza vaccine with standard dose influenza vaccine in people aged ≥65 years

 

Live attenuated influenza vaccine (LAIV; FluMist)

Children aged 2–17 years

Coversheet

Use of LAIV (FluMist) vaccine in children aged 2–17 years

GRADE assessment and ATAGI recommendation

PICO 1: Comparison of live-attenuated influenza vaccine (LAIV; FluMist) with control for prevention of influenza in children aged 2–17 years 

PICO 2: Comparison of live-attenuated influenza vaccine (LAIV; FluMist) with inactivated influenza vaccine (IIV) for prevention of influenza in children aged 2–17 years 
 

Note: These GRADE documents should be read as a supplement to Australian Immunisation Handbook recommendations.

View the Influenza disease chapter in the Handbook
View the ATAGI advice on seasonal influenza vaccines in 2026

Last updated March 2026