Meningococcal vaccines GRADE assessments

GRADE assessment of meningococcal vaccines

Meningococcal B booster vaccines (Bexsero and Trumenba)

Coversheet on evidence assessment by ATAGI using the GRADE framework for meningococcal B booster vaccine

Bexsero

GRADE assessment of Bexsero:

• compared to no booster for individuals at standard background risk of invasive meningococcal disease (IMD)
• compared to no booster for individuals at increased risk of invasive meningococcal disease (IMD)

Trumenba

GRADE assessment of Trumenba:

• compared to no booster vaccine for individuals at standard background risk of invasive meningococcal disease (IMD)
• compared to no booster vaccine for individuals at increased risk of invasive meningococcal disease (IMD)

ATAGI recommendations

• Use of Bexsero vaccine as a booster dose in individuals at standard background risk of invasive meningococcal disease
• Use of Bexsero vaccine as a booster dose in individuals at increased risk of invasive meningococcal disease
• Use of Trumenba vaccine as a booster dose in individuals at standard background risk of invasive meningococcal disease
• Use of Trumenba vaccine as a booster dose in individuals at increased risk of invasive meningococcal disease

Note
These GRADE documents should be read as a supplement to the Australian Immunisation Handbook (Handbook) recommendations.

View the Meningococcal disease chapter in the Handbook here