Comparing the inactivated influenza vaccine with the live attenuated vaccine

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This information is designed to support conversations about the administration of inactivated influenza vaccine and live attenuated influenza vaccine to children.
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Common questionsInactivated influenza vaccine Live attenuated influenza vaccine 
Recommended and registered age group
  • ≥6 months
  • 2 to <18 years
Composition
  • Inactivated influenza virus, split virion or subunit formulations
  • Trivalent – type A (H1N1), type A (H3N2) and type B (Victoria)
  • Live, contains weakened strains of the flu virus
  • Trivalent – type A (H1N1), type A (H3N2) and type B (Victoria)
Administration
  • Intramuscular injection, can be given subcutaneously
  • Can be co-administered with live and non-live vaccines
  • Administered intranasally as 2 sprays, one in each nostril
  • Can be co-administered with live and non-live vaccines
How many doses are required?
  • One annual dose is recommended for most people
  • Two doses (4 weeks apart) are recommended for:
    • healthy children aged 6 months to <2 years of age who are receiving influenza vaccine for first time
    • children aged 6 months to <9 years of age with medical risk conditions receiving influenza vaccine for the first time
    • people of any age receiving influenza vaccine for the first time after a haematopoietic stem cell transplant, solid organ transplant or chimeric antigen receptor (CAR) T-cell therapy
  • One annual dose is recommended for most people
  • Two doses (4 weeks apart) are recommended for children aged 2 years to <9 years of age who have medical risk conditions not contraindicated to LAIV and who are receiving influenza vaccine for the first time
Safety
  • The most common mild adverse events following immunisation (AEFI) are injection site reactions, fever and headache
  • The most common AEFI are nasal and throat symptoms 
Contraindications
  • Anaphylaxis to a previous dose of any influenza vaccine
  • Anaphylaxis after receipt of any component of an influenza vaccine
  • Contraindicated for people who are moderately or severely immunocompromised. Use inactivated influenza vaccine instead.
  • Anaphylaxis to a previous dose of any influenza vaccine
  • Anaphylaxis after receipt of any component of an influenza vaccine
Effectiveness
  • 50%~65% effective in healthy individuals, including young children
  • 50%–65% effective in young children
Funding eligibility for children

National Immunisation Program funding is available for:

  • all children aged ≥6 months to <5 years
  • Aboriginal and Torres Strait Islander children aged ≥6 months 
  • all children aged ≥6 months who have specified medical risk conditions

Not National Immunisation Program funded. 

Funded by state/territory governments in:

  • NSW and SA for children aged 2 to <5 years
  • Qld for children aged 2 to 5 years (inclusive)
  • WA for children aged 2 to <12 years

Individual prescription available in all states and territories.